Frontiers in Anti-Infective Drug Discovery

Volume: 4

Polysaccharide Deacetylases: New Antibacterial Drug Targets

Author(s): Stavroula Balomenou, Sofia Arnaouteli, Dimitris Koutsioulis, Vasiliki E. Fadouloglou and Vassilis Bouriotis

Pp: 68-130 (63)

DOI: 10.2174/9781681080826115040005

* (Excluding Mailing and Handling)


There is an urgent need to explore new targets and develop novel therapeutics due to the emergence of multi-drug resistant bacteria. Recently, selected members of Carbohydrate Esterase family 4 namely peptidoglycan and exopolysaccharide de-N-acetylases from bacterial pathogens have been identified as promising antibacterial drug targets. This chapter highlights the state of the art in their physiological roles, biochemical characterization, regulation, localization, structure determination and mechanism of action. Initial efforts and strategies that will guide the development of novel inhibitors against bacterial pathogens, including biofilm forming and spore forming ones, are also reviewed.

Keywords: Biofilm formation, enzyme inhibitors, lysozyme resistance, peptidoglycan deacetylases, polysaccharide deacetylases, spore formation, virulence factors.

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