Inositol & its Phosphates: Basic Science to Practical Applications

The Roles of Inositol and its Phosphates in Neuropsychiatric Disorders

Author(s): A.K.M. Shamsuddin and Guang-Yu Yang

Pp: 164-175 (12)

DOI: 10.2174/9781681080079115010015

* (Excluding Mailing and Handling)


There are experimental data showing beneficial actions of inositol and inositol hexaphosphate (InsP6) in Alzheimer’s disease and Parkinson’s disease. The different stereoisomers of inositol, myo-, epi-, scyllo- and chiro-inositol have shown efficacy in Alzheimer’s disease. The antioxidant and cation chelating properties of InsP6 are considered to be some of the mechanisms; those of myo-inositol are not clear. Insofar as psychiatric diseases, lithium salts have been in use since the 1950s for bipolar disorder. While on one hand there is reduction of myo-inositol by lithium, myo-inositol on the other hand has been found useful in psychiatric disorders, and at least in one study of bipolar disorder. Thus, further studies of myo-inositol, and InsP6 in the treatment of bipolar disorder are warranted. A clinical trial of InsP6 in bipolar disorder is underway.

Keywords: Alzheimer’s disease, BACE 1, bipolar disorder, CGI-S, HAM-D, Levodopa, lithium, MADRS, OCD, panic disorder, Parkinson’s disease, Y-BOCS.

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