Inositol & its Phosphates: Basic Science to Practical Applications

Experimental Cancer Regression by InsP6 & Inositol

Author(s): A.K.M. Shamsuddin and Guang-Yu Yang

Pp: 83-106 (24)

DOI: 10.2174/9781681080079115010009

* (Excluding Mailing and Handling)


Towards the eventual goal of translating the cancer inhibitory effect of inositol & InsP6 seen in experimental animals in vivo to cancer prevention and therapy in humans, studies of human cancer cells lines were performed in vitro; and human cancer cells xenotransplanted in nude mice were used to test the therapeutic potential. A consistent and reproducible broad-spectrum anticancer action of InsP6 ± inositol was observed in various models; in human breast cancer model InsP6 showed synergism with standard chemotherapeutic agents Adriamycin or Tamoxifen. Suppression of cancer growth was seen in xenotransplanted rhabdomyosarcoma model and regression of preexisting cancer was seen in hepatoma model. InsP6 ± inositol also inhibited various steps in cancer metastasis, inositol potentiated the action. These findings are compelling reasons for application of InsP6+inositol for human cancer control.

Keywords: Adriamycin, CEA, chemotherapeutic agent, collagen, fibronectin, haptotactic migration, HepG2, hepatoma, hepatocellular carcinoma, laminin, MCF-7, MDA MB 231, metastasis, MMP, nude mice, Tamoxifen, TRAMP, synergism, xenotransplantation.

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