Inositol & its Phosphates: Basic Science to Practical Applications

Experimental Cancer Prevention by InsP6 & Inositol

Author(s): A.K.M. Shamsuddin and Guang-Yu Yang

Pp: 67-82 (16)

DOI: 10.2174/9781681080079115010008

* (Excluding Mailing and Handling)


Myo-inositol and InsP6 have independent anticancer action against divergent types of malignancies in a consistent and reproducible manner. The anti-cancer action is dose-dependent and inositol acts synergistically with InsP6 to enhance the anticancer action of the latter. Since inositol and InsP6 are common constituents of cereals and legumes, comparative study of high bran diet with equivalent amount of InsP6 showed that while the ‘high fiber’ diet failed to reduce the incidence of experimental cancer, InsP6 alone at equivalent dose significantly inhibited mammary cancer formation. Combined with the other studies, these data strongly suggest that supplementation with pure inositol + InsP6 may be better than gobbling a large amount of fiber.

Keywords: AOM, CD, colitis, Crohn’s disease, DMBA, DMH, pre-initiation, post-initiation, tumor promoter, UC, ulcerative colitis.

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