Inositol & its Phosphates: Basic Science to Practical Applications

Pharmacokinetics of InsP6

Author(s): A.K.M. Shamsuddin and Guang-Yu Yang

Pp: 57-66 (10)

DOI: 10.2174/9781681080079115010007

* (Excluding Mailing and Handling)


Studies have shown that InsP6 is rapidly absorbed from the gastrointestinal tract, distributed through the plasma to various organs including the brain, and excreted from the lungs via exhaled air and through the kidneys via urine as inositol, InsP1-5 and InsP6. That it is distributed in brain indicates that it crosses the blood-brain barrier. Also challenging the dogma is that at least in mice, InsP6 is distributed in the red blood cells as well. InsP6 is rapidly taken up by malignant cells wherein it is precipitously dephosphorylated to various lower phosphates; depending on the cell types, the proportion of these lower inositol phosphates varies. Inositol is also rapidly absorbed by humans.

Keywords: Blood-brain barrier, GC-MS, internalization, red blood cells, visualization.

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