Advances in Anticancer Agents in Medicinal Chemistry

Volume: 2

Tripentones: A Promising Series of Potent Anti-Cancer Agents

Author(s): Christophe Rochais, Sylvain Rault and Patrick Dallemagne

Pp: 313-343 (31)

DOI: 10.2174/9781608054961113020009

* (Excluding Mailing and Handling)


The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anticancer agents. These compounds belong to the tripentone family and are based on 9Hpyrrolo[ 1,2-a]indol-9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.

Keywords: Tripentone, pyrrolizinone, pyrroloindolone, thiophene, cancer, pyrrole , heterocycles, clauson-kaas, acylation, ring closure.

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