Frontiers in Drug Design and Discovery

Volume: 2

NMR-Based Metabonomics of Urine from An Exploratory Study of Ciprofibrate in Healthy Volunteers and Patients with Type 2 Diabete

Author(s): Gregory C. Leo, Ewoud J. van Hoogdalem and Martijn B.A. van Doorn

Pp: 175-191 (17)

DOI: 10.2174/978160805200410602010175

* (Excluding Mailing and Handling)


This report presents the results from the NMR-based metabonomics of urine collected as part of a multiple dose, double-blind, randomized, placebo controlled parallel group exploratory study of the pharmacodynamics of ciprofibrate in healthy volunteers and patients with type 2 Diabetes Mellitus. Using supervised statistical analysis it was possible to distinguish the various treatment groups (healthy and diabetic: placebo-treated or drug-treated) when males and females were analyzed separately.

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