Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases

Taurine as an Anti-aging Compound: Focus on Mitochondria-related Mechanisms

Author(s): Reza Heidari and M. Mehdi Ommati

Pp: 137-173 (37)

DOI: 10.2174/9789815124484123010008

* (Excluding Mailing and Handling)


 It has been well-established that mitochondria play a crucial role in aging. Thus, targeting mitochondria is a leading approach for anti-aging pharmacological interventions. On the other hand, the anti-aging effect of taurine (TAU) is an exciting feature of this amino acid. Effects of TAU on mitochondria-facilitated oxidative stress as well as mitochondria-mediated cell death, seem to play a pivotal role in its antiaging properties. The current chapter will discuss a good body of investigations that have converged at a consensus regarding mitochondria (dynamics and functionality) and oxidative stress as essential mechanisms involved in the aging process. In each part, the potential antiaging properties of TAU and its mechanisms of action are also highlighted. Finally, in the last section of this chapter, we described the possible role of recently-discovered signaling pathways (i.e., aryl hydrocarbon receptors; AhR) on mitochondria and their relevance to senescence. 

Keywords: Cell death, Endoplasmic reticulum stress, Oxidative stress, Reproduction, Senescence.

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