Nanoparticles and Nanocarriers Based Pharmaceutical Formulations

Lipoidal Carrier as Drug Delivery System

Author(s): Bina Gidwani, Priya Namdeo, Sakshi Tiwari, Atul Tripathi, Ravindra Kumar Pandey, Shiv Shankar Shukla, Veenu Joshi, Vishal Jain, Suresh Thareja and Amber Vyas *

Pp: 273-302 (30)

DOI: 10.2174/9789815049787122010012

* (Excluding Mailing and Handling)


The delivery system plays a vital role in managing the pharmacokinetics and pharmacodynamics of a drug. The size of the carrier system contributes to its pharmacological action. Lipid-based carriers refer to the formulations containing a dissolved or suspended drug in lipidic excipients. Lipoidal systems as carriers are achieving heights due to their significant lipid nature and the size of particles in the delivery system. The micro/nano-sized lipid-based carriers possess versatility in improving the physic-chemical properties of drugs. Also, they are biocompatible and can be administered through all possible routes. Lipid-based drug delivery carrier systems of new and existing formulations can be commercialized to achieve the desired range of product specifications. Solubility of the drug in various lipids is a key factor in the development of the delivery system. Lipids as functional excipients are compatible with solid, liquid, and semi-solid dosage forms. Besides improving/enhancing the solubility and bioavailability, lipids provide multiple broad-based applications in the pharmaceutical delivery system.

Keywords: Bioavailability, BCS Class, Cancer, Carriers, Delivery system, Lipids, Micro/nano, Pharmacokinetics, Pharmacodynamics, Solubility, Liposomes, Solid Lipid Nanoparticles, Nanostructured lipid carrier, Lipid-drug conjugate, Liposphere, Topical, Oral, Parenteral, Pulmonary, Protein/peptide.

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