Nanoparticles and Nanocarriers Based Pharmaceutical Formulations

Gastro-retentive Nanocarriers in Drug Delivery

Author(s): Kuldeep Rajpoot*, Sunil K. Jain and Saroj Dangi Rajpoot

Pp: 175-196 (22)

DOI: 10.2174/9789815049787122010009

* (Excluding Mailing and Handling)


The oral route is an extremely accepted route for the administration of several drug delivery systems. This route exhibits several merits for the controlled and sustained release of different formulation types to attain enhanced therapeutic responses. Gastro-retentive nanocarriers (NCs) (GRNCs) have advantages due to their aptitude for extended retaining potential in the stomach environment and thereby elevate gastric retention and augmenting bioavailability of the drug molecules. This chapter covers various merits and demerits of gastro-retentive NCs. Further, it also discusses some gastro-retentive strategies and their applications in the therapy of various illnesses, for instance, swelling NCs, porous NCs, floating/non-floating NCs, lipid NCs, Polymeric NCs, bioadhesive NCs, and magnetic NCs, etc. 

Keywords: Bioavailability, Controlled drug release, Drug delivery, Eudragit L100, Floating systems, Gastric cancer, Gastro-retentive carriers, Gastric retention time, Gastric emptying time, Gastrointestinal, HPMC, Ion-exchange resin, Lipids nanocarriers, Mucoadhesive nanocarriers, Magnetic nanocarriers, Polymer, Polymeric nanocarriers, Stomach, Sustained drug release, Super porous systems.

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