Frontiers in Natural Product Chemistry

Volume: 8

Coumarin Derivatives as Potential Antiinflammatory Agents for Drug Development

Author(s): Abdul Jalil Shah, Reyaz Hassan Mir, Roohi Mohi-ud-din*, Saba Hussain Sabreen, Nazia Banday, Mudasir Maqbool Bhat and Mubashir Hussain Masoodi *

Pp: 213-238 (26)

DOI: 10.2174/9781681089379121080008

* (Excluding Mailing and Handling)


The search for anti-inflammatory drugs is still challenging, even though recent advances in modern medicine have provided some relief. Coumarins, well known secondary metabolites widely distributed in plant kingdom, have successfully documented their candidature in the development of anti-inflammatory agents. Natural coumarins, including esculetin, umbelliferone, scopoletin and marmin showed potent anti-inflammatory activity through various targets, including COX-2, LOX, iNOS TNF-α, TXB2. Over the past decade, various synthetic modifications have been carried out on the scaffold of these natural products. The current review focuses on various synthetic and semi-synthetic modifications carried out on the coumarin nucleus with a primary focus on the evaluation of anti-inflammatory activity along with structureactivity relationship study.

Keywords: Anti-Inflammatory agents, Cox-2, Natural Coumarins, SAR, Synthetic Analogs.

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