Bentham Briefs in Biomedicine and Pharmacotherapy Oxidative Stress and Natural Antioxidants

Antioxidants in Cancer Prevention and Combination Therapy

Author(s): Safura Nisar, Basharat Ahmad Bhat, Umar Mehraj, Hina Qayoom, Wajahat Rashid Mir and Manzoor Ahmad Mir *

Pp: 446-463 (18)

DOI: 10.2174/9789814998871121010020

* (Excluding Mailing and Handling)


Combination therapy, also known as polytherapy, is a form of treatment that involves the use of several drugs. In fact, the term applies to the use of various treatments to cure a particular illness, with pharmaceutical therapies being the most common. Non-medical treatment, such as the use of a mixture of medications and psychotherapy to relieve depression, may also be used. Polypharmacy, which applies to the usage of multiple medications, is also a related term. When referring to prescription combination treatment, the term polymedicine is also used. The antioxidant protection mechanism, which is responsible for reducing a wide variety of oxidants like reactive oxygen species (ROS), lipid peroxides, and metals, etc., maintains redox homeostasis. Antioxidants are used to guard against the harmful consequences of oxidation and as nutritional additives to counteract the negative effects of stress. Antioxidants are compounds that may prevent or delay cell damage induced by free radicals, which are reactive molecules produced by the body in response to external environmental and other stress. Free-radical scavengers is a term used to describe them. Antioxidants may come from either natural or synthetic sources. Many plant-based foods are thought to have high levels of antioxidants. Plant-based antioxidants are phytonutrients that contribute to disease prevention. These phytonutrients as single entity or in combination have demonstrated beneficial effects in several models and might protect against cancer.

Keywords: Antioxidants, Cancer, Carotenoids, Chemotherapy, Combinational therapy, Free-radicals, Homeostasis, Immunity, Oxidative stress, Reactive oxygen species, Scavengers, Therapeutics, Tumor, Zeaxanthin.

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