Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair

In Vivo Effects of Amelogenins on Reparative Dentin Formation

Author(s): Yassine Harichane, Sasha Dimitrova-Nakov, Anne Poliard, Arthur Veis, Pamela DenBesten, Odile Kellermann, Michel Goldberg

Pp: 174-190 (17)

DOI: 10.2174/978160805171711001010174

* (Excluding Mailing and Handling)


Two low molecular weight amelogenin gene splice products (A+4 and A-4), used for pulp capping after surgical pulp exposure in the rat first maxillary molars, have been shown to induce the formation of a reparative dentinal bridge. A-4 can induce mineralization of the atubular orthodentinal type to totally fill the root pulp canal with a homogeneous mineralized structure. The two molecules recruit latent adult pulp progenitors to form actively dividing cells, which differentiated into cells bearing an osteoblast-odontoblast phenotype to produce an extracellular matrix implemented in reparative mineralization. We conclude that pulp capping with bioactive molecules will direct new approaches in biodentistry.

Keywords: Dental Pulp, Progenitor Cells, Amelogenin Splice Products, Pulp Capping, Biodentistry

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